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Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation‐Induced Emission for Evaluation of Blood–Brain Barrier Damage
Author(s) -
Cai Xiaolei,
Bandla Aishwarya,
Mao Duo,
Feng Guangxue,
Qin Wei,
Liao LunDe,
Thakor Nitish,
Tang Ben Zhong,
Liu Bin
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601191
Subject(s) - biocompatibility , evans blue , materials science , blood–brain barrier , in vivo , nanoparticle , fluorescence , biocompatible material , nanotechnology , biophysics , biomedical engineering , medicine , central nervous system , neuroscience , biology , physics , microbiology and biotechnology , quantum mechanics , metallurgy , endocrinology
Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation‐induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.