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Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery
Author(s) -
Kang Homan,
Gravier Julien,
Bao Kai,
Wada Hideyuki,
Lee Jeong Heon,
Baek Yoonji,
El Fakhri Georges,
Gioux Sylvain,
Rubin Brian P.,
Coll JeanLuc,
Choi Hak Soo
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601101
Subject(s) - nanocarriers , clearance , drug delivery , materials science , nanotechnology , drug , targeted drug delivery , drug carrier , polylysine , pharmacology , chemistry , medicine , organic chemistry , urology
Renally cleared zwitterionic nanocarriers (H‐Dots) are composed of ε‐polylysine backbone for charge variations, near‐infrared fluorophores for bioimaging, and β‐cyclodextrins for potential drug delivery. H‐Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.