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Superfluorinated PEI Derivative Coupled with 99m Tc for ASGPR Targeted 19 F MRI/SPECT/PA Tri‐Modality Imaging
Author(s) -
Guo Zhide,
Gao Mengna,
Song Manli,
Li Yesen,
Zhang Deliang,
Xu Duo,
You Linyi,
Wang Liangliang,
Zhuang Rongqiang,
Su Xinhui,
Liu Ting,
Du Jin,
Zhang Xianzhong
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601064
Subject(s) - asialoglycoprotein receptor , polyethylenimine , spect imaging , nuclear medicine , medical physics , materials science , computer science , radiochemistry , medicine , chemistry , biochemistry , hepatocyte , transfection , in vitro , gene
Fluorinated polyethylenimine derivative labeled with radionuclide 99m Tc is developed as a 19 F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)‐targeting ability. This multifunctional agent is safe and suitable for 19 F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.