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Double‐Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration
Author(s) -
oyama Takayuki,
Wada Susumu,
Kiyama Ryuji,
Kitamura Nobuto,
Mredha Md.Tariful Islam,
Zhang Xi,
Kurokawa Takayuki,
Nakajima Tasuku,
Takagi Yasuaki,
Yasuda Kazunori,
Gong Jian Ping
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201601030
Subject(s) - materials science , self healing hydrogels , penetration (warfare) , polymer chemistry , engineering , operations research
On implanting hydroxyapatite‐mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi‐permeablility of the hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.