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Tunable Thermal‐Sensitive Polymer–Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells
Author(s) -
Yoon Hyeun Joong,
Shanker Apoorv,
Wang Yang,
Kozminsky Molly,
Jin Qu,
Palanisamy Nallasivam,
Burness Monika L.,
Azizi Ebrahim,
Simeone Diane M.,
Wicha Max S.,
Kim Jinsang,
Nagrath Sunitha
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201600658
Subject(s) - graphene , materials science , circulating tumor cell , oxide , microfluidics , surface modification , polymer , composite number , nanotechnology , chemical engineering , cancer , composite material , medicine , engineering , metallurgy , metastasis
A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis.