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Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy
Author(s) -
Zhang Ran,
Li Yan,
Hu Bingbing,
Lu Zhiguo,
Zhang Jinchao,
Zhang Xin
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201600554
Subject(s) - neural stem cell , transplantation , retinoic acid , neuroscience , stem cell , materials science , nanoparticle , small interfering rna , nanotechnology , biology , rna , microbiology and biotechnology , medicine , cell culture , biochemistry , genetics , gene
Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.