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Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All‐Function‐in‐One Chimeric Polymersomes
Author(s) -
Yang Weijing,
Zou Yan,
Meng Fenghua,
Zhang Jian,
Cheng Ru,
Deng Chao,
Zhong Zhiyuan
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201600065
Subject(s) - polymersome , in vivo , methotrexate , cancer research , materials science , pharmacology , drug delivery , nanotechnology , medicine , biology , microbiology and biotechnology , composite material , copolymer , amphiphile , polymer
Anisamide‐functionalized reversibly crosslinked chimeric polymersomes emerge as an “all‐function‐in‐one” nanoplatform for efficient loading and targeted delivery of methotrexate disodium, a potent water‐soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor‐growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall).