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Stimuli‐Responsive Materials: Enzyme‐Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction (Adv. Mater. 37/2015)
Author(s) -
Nguyen Mary M.,
Carlini Andrea S.,
Chien MiaoPing,
Sonnenberg Sonya,
Luo Colin,
Braden Rebecca L.,
Osborn Kent G.,
Li Yiwen,
Gianneschi Nathan C.,
Christman Karen L.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570243
Subject(s) - myocardial infarction , microscale chemistry , materials science , nanoparticle , enzyme , nanotechnology , infarction , biophysics , cardiology , biomedical engineering , medicine , biochemistry , chemistry , biology , mathematics education , mathematics
Stimuli‐responsive nanoparticles, when injected systemically, circulate in the blood stream until reaching the site of myocardial infarction (MI). As reported by N. C. Gianneschi, K. L. Christman, and co‐workers on page 5547, recognition by infarct‐associated enzymes induces a morphology transition, triggering the subsequent aggregation of nanoparticles at the site of damage. The resulting microscale aggregates exhibit prolonged retention in the infarct, thereby providing a potential platform for delivering therapeutics to an acute MI.