Premium
Tumor Microenvironments: Rapid 3D Extrusion of Synthetic Tumor Microenvironments (Adv. Mater. 37/2015)
Author(s) -
Grolman Joshua M.,
Zhang Douglas,
Smith Andrew M.,
Moore Jeffrey S.,
Kilian Kristopher A.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570242
Subject(s) - materials science , self healing hydrogels , nanotechnology , tumor microenvironment , tissue engineering , extrusion , breast tumor , tumor cells , biomedical engineering , cancer research , polymer chemistry , composite material , biology , cancer , engineering , genetics , breast cancer
The generation of cell‐laden spatially organized 3D hydrogels is demonstrated by K. A. Kilian and co‐workers on page 5512, using macrophages and breast adenocarcinoma cells as a heterotypic model that mimics aspects of the tumor microenvironment. This versatile and tunable approach for fabricating soft materials in organized architectures may prove useful for engineering model systems for therapeutic development, and scaffolds for tissue engineering.