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Hydrogels: Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport (Adv. Mater. 28/2015)
Author(s) -
Kim Minkyu,
Chen Wesley G.,
Kang Jeon Woong,
Glassman Matthew J.,
Ribbeck Katharina,
Olsen Bradley D.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570191
Subject(s) - self healing hydrogels , materials science , nucleoporin , nanotechnology , polymer chemistry , nuclear protein , chemistry , biochemistry , transcription factor , gene
Nucleoporin‐like polypeptide (NLP) hydrogels are developed by B. D. Olsen and co‐workers on page 4207 by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.