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Hydrogels: Hydrogel Retaining Toxin‐Absorbing Nanosponges for Local Treatment of Methicillin‐Resistant Staphylococcus aureus Infection (Adv. Mater. 22/2015)
Author(s) -
Wang Fei,
Gao Weiwei,
Thamphiwatana Soracha,
Luk Brian T.,
Angsantikul Pavimol,
Zhang Qiangzhe,
Hu CheMing J.,
Fang Ronnie H.,
Copp Jonathan A.,
Pornpattananangkul Dissaya,
Lu Weiyue,
Zhang Liangfang
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570149
Subject(s) - self healing hydrogels , staphylococcus aureus , methicillin resistant staphylococcus aureus , materials science , microbiology and biotechnology , toxin , virulence , chemistry , bacteria , biology , polymer chemistry , genetics , biochemistry , gene
On page 3437, L. Zhang and co‐workers describe a hybrid nanomaterial, integrating unique toxin‐absorbing nanosponges with hydrogels, that is developed for local anti‐virulence therapy against methicillin‐resistant Staphylococcus aureus (MRSA) infection. The hydrogel effectively retains the toxic nanosponges post administration without compromising toxin transport into the gel for neutralization. The nanosponge–hydrogel hybrid markedly reduces MRSA skin lesion development in a mouse model.