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Hydrogels: In‐Situ Formation of Growth‐Factor‐Loaded Coacervate Microparticle‐Embedded Hydrogels for Directing Encapsulated Stem Cell Fate (Adv. Mater. 13/2015)
Author(s) -
Jeon Oju,
Wolfson David W.,
Alsberg Eben
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570090
Subject(s) - self healing hydrogels , coacervate , materials science , microparticle , in situ , poly(n isopropylacrylamide) , nanotechnology , chemical engineering , polymer chemistry , composite material , chemistry , copolymer , organic chemistry , polymer , engineering
E. Alsberg and co‐workers demonstrate the spontaneous formation of coacervate microdroplets and/or coacervate‐laden photo‐crosslinked hydrogels derived from the simple mixing of photo‐crosslinkable methacrylated alginate and methacrylated gelatin over a wide pH range at room temperature, as described on page 2216. This system can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulated stem cells for therapeutic applications.