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Gene Delivery: Large‐Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co‐templating Assembly and Nuclear‐Targeted Gene Delivery (Adv. Mater. 2/2015)
Author(s) -
Wu Meiying,
Meng Qingshuo,
Chen Yu,
Du Yanyan,
Zhang Lingxia,
Li Yaping,
Zhang Linlin,
Shi Jianlin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201570008
Subject(s) - materials science , nanoparticle , micelle , mesoporous organosilica , mesoporous material , nanotechnology , mesoporous silica , gene delivery , conjugated system , chemical engineering , organic chemistry , catalysis , gene , polymer , chemistry , transfection , biochemistry , aqueous solution , engineering , composite material
Mesoporous organosilica nanoparticles (MONs) with concurrent well‐defined large pores, small particle sizes, and unique molecularly organic‐inorganic hybrid compositions are successfully synthesized by Y. Chen, Y. Li, J. Shi, and co‐workers on page 215, via a novel micelle/precursor co‐templating assembly (M/P‐CA) strategy. Furthermore, a MONs‐PTAT conjugated system is constructed for nuclear‐targeted direct transportation of plasmids.