Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery | Zendy

Ye Yanqi | Zendy; Yu Jicheng | Zendy; Wang Chao | Zendy; Nguyen NhuY | Zendy; Walker Glenn M. | Zendy; Buse John B. | Zendy; Gu Zhen | Zendy

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Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery

Author(s) -

Ye Yanqi,

Yu Jicheng,

Wang Chao,

Nguyen NhuY,

Walker Glenn M.,

Buse John B.,

Gu Zhen

Publication year - 2016

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201506025

Subject(s) - materials science , insulin delivery , insulin , signal (programming language) , nanotechnology , amplifier , optoelectronics , medicine , endocrinology , diabetes mellitus , biology , computer science , type 1 diabetes , cmos , programming language

An innovative microneedle (MN)‐based cell therapy is developed for glucose‐responsive regulation of the insulin secretion from exogenous pancreatic β ‐cells without implantation. One MN patch can quickly reduce the blood‐sugar levels (BGLs) of chemically induced type‐1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.

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