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Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery
Author(s) -
Ye Yanqi,
Yu Jicheng,
Wang Chao,
Nguyen NhuY,
Walker Glenn M.,
Buse John B.,
Gu Zhen
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201506025
Subject(s) - materials science , insulin , insulin delivery , secretion , blood sugar , medicine , pharmacology , endocrinology , nanotechnology , diabetes mellitus , type 1 diabetes
An innovative microneedle (MN)‐based cell therapy is developed for glucose‐responsive regulation of the insulin secretion from exogenous pancreatic β ‐cells without implantation. One MN patch can quickly reduce the blood‐sugar levels (BGLs) of chemically induced type‐1 diabetic mice and stabilize BGLs at a reduced level for over 10 h.