Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy | Zendy

Qian Chenggen | Zendy; Yu Jicheng | Zendy; Chen Yulei | Zendy; Hu Quanyin | Zendy; Xiao Xuanzhong | Zendy; Sun Wujin | Zendy; Wang Chao | Zendy; Feng Peijian | Zendy; Shen QunDong | Zendy; Gu Zhen | Zendy

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Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy

Author(s) -

Qian Chenggen,

Yu Jicheng,

Chen Yulei,

Hu Quanyin,

Xiao Xuanzhong,

Sun Wujin,

Wang Chao,

Feng Peijian,

Shen QunDong,

Gu Zhen

Publication year - 2016

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201505869

Subject(s) - nanocarriers , materials science , nanotechnology , hypoxia (environmental) , cancer research , tumor hypoxia , cancer therapy , drug delivery , cancer , medicine , radiation therapy , oxygen , chemistry , organic chemistry

A light‐activated hypoxia‐responsive conjugated polymer‐based nanocarrier is developed for efficiently producing singlet oxygen ( 1 O 2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual‐responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug‐release modality.

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