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Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy
Author(s) -
Qian Chenggen,
Yu Jicheng,
Chen Yulei,
Hu Quanyin,
Xiao Xuanzhong,
Sun Wujin,
Wang Chao,
Feng Peijian,
Shen QunDong,
Gu Zhen
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201505869
Subject(s) - nanocarriers , singlet oxygen , materials science , photodynamic therapy , hypoxia (environmental) , nanotechnology , conjugated system , tumor hypoxia , drug , drug delivery , nanocapsules , pharmacology , polymer , medicine , nanoparticle , oxygen , chemistry , radiation therapy , organic chemistry , composite material
A light‐activated hypoxia‐responsive conjugated polymer‐based nanocarrier is developed for efficiently producing singlet oxygen ( 1 O 2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual‐responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug‐release modality.