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Directed Assembly and Development of Material‐Free Tissues with Complex Architectures
Author(s) -
Vrij Erik,
Rouwkema Jeroen,
LaPointe Vanessa,
van Blitterswijk Clemens,
Truckenmüller Roman,
Rivron Nicolas
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201505723
Subject(s) - template , scaffold , nanotechnology , computer science , materials science , service (business) , extracellular matrix , biology , database , microbiology and biotechnology , economy , economics
Material‐free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter‐scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self‐scaffold by secreting extracellular matrix, and undergo morphogenesis.