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Large Pore‐Sized Hollow Mesoporous Organosilica for Redox‐Responsive Gene Delivery and Synergistic Cancer Chemotherapy
Author(s) -
Wu Meiying,
Meng Qingshuo,
Chen Yu,
Zhang Lingxia,
Li Mengli,
Cai Xiaojun,
Li Yaping,
Yu Pengcheng,
Zhang Linlin,
Shi Jianlin
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201505524
Subject(s) - materials science , doxorubicin , mesoporous organosilica , nanotechnology , drug delivery , multiple drug resistance , cancer cell , redox , mesoporous material , fabrication , nanoparticle , cancer , mesoporous silica , chemotherapy , drug resistance , organic chemistry , chemistry , catalysis , medicine , biology , alternative medicine , surgery , pathology , metallurgy , microbiology and biotechnology
A stability‐difference‐selective bond‐breakage strategy for the fabrication of largepore‐sized hollow mesoporous organosilica nanoparticles (HMONs) is successfully developed. Moreover, surfacefunctionalized HMONs are successfully constructed to simultaneously deliver P‐gp modulator siRNA and anticancer drug doxorubicin to reverse the multidrug resistance of cancer cells.