Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction | Zendy

Yang Yunlong | Zendy; Zhang Jieyuan | Zendy; Liu Zhenzhen | Zendy; Lin Qiuning | Zendy; Liu Xiaolin | Zendy; Bao Chunyan | Zendy; Wang Yang | Zendy; Zhu Linyong | Zendy

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Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

Author(s) -

Yang Yunlong,

Zhang Jieyuan,

Liu Zhenzhen,

Lin Qiuning,

Liu Xiaolin,

Bao Chunyan,

Wang Yang,

Zhu Linyong

Publication year - 2016

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201505336

Subject(s) - imine , biocompatible material , covalent bond , materials science , aldehyde , hyaluronic acid , polymer , nitrobenzene , process (computing) , computer science , nanotechnology , organic chemistry , chemistry , biomedical engineering , engineering , biology , genetics , composite material , catalysis , operating system

A novel photogelling mechanism by the phototriggered‐imine‐crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o‐nitrobenzene, a photogenerated aldehyde group, can quickly photo‐crosslink with amino‐bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.

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