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Tissue‐Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction
Author(s) -
Yang Yunlong,
Zhang Jieyuan,
Liu Zhenzhen,
Lin Qiuning,
Liu Xiaolin,
Bao Chunyan,
Wang Yang,
Zhu Linyong
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201505336
Subject(s) - imine , biocompatible material , covalent bond , materials science , aldehyde , hyaluronic acid , polymer , nitrobenzene , process (computing) , computer science , nanotechnology , organic chemistry , chemistry , biomedical engineering , engineering , biology , genetics , composite material , catalysis , operating system
A novel photogelling mechanism by the phototriggered‐imine‐crosslinking (PIC) reaction is demonstrated. Hyaluronic acid grafted with o‐nitrobenzene, a photogenerated aldehyde group, can quickly photo‐crosslink with amino‐bearing polymers or proteins. Once the in situ photogelling on a wound occurs, the PIC gelling process can well integrate a hydrogel with surrounding tissue by covalent bonding, thus making it a powerful tool for tissue engineering and regenerative medicine.