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Bio‐Inspired Mechanotactic Hybrids for Orchestrating Traction‐Mediated Epithelial Migration
Author(s) -
Cai Pingqiang,
Layani Michael,
Leow Wan Ru,
Amini Shahrouz,
Liu Zhiyuan,
Qi Dianpeng,
Hu Benhui,
Wu YunLong,
Miserez Ali,
Magdassi Shlomo,
Chen Xiaodong
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201505300
Subject(s) - materials science , traction (geology) , stiffness , extracellular matrix , planar , coupling (piping) , layer (electronics) , computer science , nanotechnology , composite material , mechanical engineering , biology , microbiology and biotechnology , computer graphics (images) , engineering
A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic coupling of epithelial migration with the stiffness of the extracellular matrix (ECM) is found to be independent of the interfacial compositional and topographical cues.