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Development of an Amino Acid‐Functionalized Fluorescent Nanocarrier to Deliver a Toxin to Kill Insect Pests
Author(s) -
Zheng Yang,
You Shusen,
Ji Chendong,
Yin Meizhen,
Yang Wantai,
Shen Jie
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201504993
Subject(s) - nanocarriers , bacillus thuringiensis , cytotoxicity , amino acid , bacillus subtilis , fluorescence , toxin , materials science , surface modification , biology , ricinoleic acid , biochemistry , drug delivery , combinatorial chemistry , microbiology and biotechnology , nanotechnology , chemistry , bacteria , in vitro , physics , quantum mechanics , genetics , castor oil
Large‐scale cultivation of Bacillus thuringiensis Berliner (Bt) crops has led to the rapid development of drug resistance. Herein, a fluorescent star poly(amino acid) is synthesized with l ‐isoleucine functionalization for the efficient delivery of either positively or negatively charged exogenous proteins into live cells. Poly(amino acid)s (P1)/Cry1Ab complexes greatly increase the cytotoxicity of the Bt toxin, Cry1Ab, and efficiently kill Bt‐resistant pests.