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Site‐Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract
Author(s) -
Schulz Jessica D.,
Patt Melanie,
Basler Sophie,
Kries Hajo,
Hilvert Donald,
Gauthier Marc A.,
Leroux JeanChristophe
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201504797
Subject(s) - polymer , endopeptidase , gastrointestinal tract , materials science , enzyme , conjugated system , cysteine , nanotechnology , combinatorial chemistry , computational biology , biochemistry , computer science , biology , chemistry , composite material
The site‐specific conjugation of polymers to multiple engineered cysteine residues of a prolyl endopeptidase leads to its stabilization in the gastrointestinal tract of rats, without compromising the activity relative to the native enzyme. The importance of polymer attachment sites is investigated, as well as the significance of polymer structure.