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Perfluorocarbon‐Loaded Hollow Bi 2 Se 3 Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer
Author(s) -
Song Guosheng,
Liang Chao,
Yi Xuan,
Zhao Qi,
Cheng Liang,
Yang Kai,
Liu Zhuang
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201504617
Subject(s) - nanoparticle , materials science , infrared , oxygen , radiation , nanotechnology , radiation therapy , energy exchange , optoelectronics , optics , chemistry , medicine , physics , organic chemistry , atmospheric sciences , geology
Hollow Bi 2 Se 3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X‐ray‐absorbing ability to locally concentrate radiation energy in the tumor, but also employing near‐infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia‐associated radio‐resistance.