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Fusogenic Reactive Oxygen Species Triggered Charge‐Reversal Vector for Effective Gene Delivery
Author(s) -
Liu Xin,
Xiang Jiajia,
Zhu Dingcheng,
Jiang Liming,
Zhou Zhuxian,
Tang Jianbin,
Liu Xiangrui,
Huang Yongzhuo,
Shen Youqing
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201504288
Subject(s) - reactive oxygen species , cytosol , intracellular , cationic polymerization , membrane , biophysics , gene delivery , materials science , oxygen , polymer , doxorubicin , vector (molecular biology) , biology , transfection , gene , biochemistry , polymer chemistry , chemistry , recombinant dna , organic chemistry , genetics , chemotherapy , composite material , enzyme
A novel fusogenic lipidic polyplex (FLPP) vector is designed to fuse with cell membranes, mimicking viropexis, and eject the polyplex into the cytosol, where the cationic polymer is subsequently oxidized by intracellular reactive oxygen species and converts to being negatively charged, efficiently releasing the DNA. The vector delivering suicide gene achieves significantly better inhibition of tumor growth than doxorubicin.