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3D Biomaterial Microarrays for Regenerative Medicine: Current State‐of‐the‐Art, Emerging Directions and Future Trends
Author(s) -
Gaharwar Akhilesh K.,
Arpanaei Ayyoob,
Andresen Thomas L.,
DolatshahiPirouz Alireza
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503918
Subject(s) - biomaterial , regenerative medicine , tissue engineering , materials science , nanotechnology , stem cell , dna microarray , biomedical engineering , biology , microbiology and biotechnology , engineering , biochemistry , gene expression , gene
Three dimensional (3D) biomaterial microarrays hold enormous promise for regenerative medicine because of their ability to accelerate the design and fabrication of biomimetic materials. Such tissue‐like biomaterials can provide an appropriate microenvironment for stimulating and controlling stem cell differentiation into tissue‐specific lineages. The use of 3D biomaterial microarrays can, if optimized correctly, result in a more than 1000‐fold reduction in biomaterials and cells consumption when engineering optimal materials combinations, which makes these miniaturized systems very attractive for tissue engineering and drug screening applications.