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Mitochondrion‐Specific Live‐Cell Bioprobe Operated in a Fluorescence Turn‐On Manner and a Well‐Designed Photoactivatable Mechanism
Author(s) -
Gu Xinggui,
Zhao Engui,
Lam Jacky W. Y.,
Peng Qian,
Xie Yujun,
Zhang Yilin,
Wong Kam Sing,
Sung Herman H. Y.,
Williams Ian D.,
Tang Ben Zhong
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503751
Subject(s) - intramolecular force , fluorescence , mitochondrion , biophysics , cell , turn (biochemistry) , materials science , combinatorial chemistry , mechanism (biology) , nanotechnology , chemistry , stereochemistry , biochemistry , biology , optics , physics , philosophy , epistemology
A novel mitochondrion‐specific live‐cell fluorescence turn‐on photoactivatable bioprobe , named o ‐TPP3M, is designed and readily prepared, operating in a new photoactivatable mechanism based on a twisted intramolecular charge‐transfer effect, the restriction of intramolecular rotations, and photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior, a large signal‐to‐background ratio, and no cytotoxicity to living cells, providing a promising candidate for varied bioresearch.