Mitochondrion‐Specific Live‐Cell Bioprobe Operated in a Fluorescence Turn‐On Manner and a Well‐Designed Photoactivatable Mechanism | Zendy

Gu Xinggui | Zendy; Zhao Engui | Zendy; Lam Jacky W. Y. | Zendy; Peng Qian | Zendy; Xie Yujun | Zendy; Zhang Yilin | Zendy; Wong Kam Sing | Zendy; Sung Herman H. Y. | Zendy; Williams Ian D. | Zendy; Tang Ben Zhong | Zendy

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Mitochondrion‐Specific Live‐Cell Bioprobe Operated in a Fluorescence Turn‐On Manner and a Well‐Designed Photoactivatable Mechanism

Author(s) -

Gu Xinggui,

Zhao Engui,

Lam Jacky W. Y.,

Peng Qian,

Xie Yujun,

Zhang Yilin,

Wong Kam Sing,

Sung Herman H. Y.,

Williams Ian D.,

Tang Ben Zhong

Publication year - 2015

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201503751

Subject(s) - intramolecular force , fluorescence , mitochondrion , biophysics , cell , turn (biochemistry) , materials science , combinatorial chemistry , mechanism (biology) , nanotechnology , chemistry , stereochemistry , biochemistry , biology , optics , physics , philosophy , epistemology

A novel mitochondrion‐specific live‐cell fluorescence turn‐on photoactivatable bioprobe , named o ‐TPP3M, is designed and readily prepared, operating in a new photoactivatable mechanism based on a twisted intramolecular charge‐transfer effect, the restriction of intramolecular rotations, and photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior, a large signal‐to‐background ratio, and no cytotoxicity to living cells, providing a promising candidate for varied bioresearch.

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