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Bottom‐Up Instructive Quality Control in the Biofabrication of Smart Protein Materials
Author(s) -
Rueda Fabián,
Céspedes María Virtudes,
ConchilloSolé Oscar,
SánchezChardi Alejandro,
SerasFranzoso Joaquin,
Cubarsi Rafael,
Gallardo Alberto,
Pesarrodona Mireia,
FerrerMiralles Neus,
Daura Xavier,
Vázquez Esther,
GarcíaFruitós Elena,
Mangues Ramón,
Unzueta Ugutz,
Villaverde Antonio
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503676
Subject(s) - biofabrication , materials science , nanotechnology , biodistribution , in vivo , fabrication , nanoparticle , biomedical engineering , biology , microbiology and biotechnology , engineering , medicine , tissue engineering , alternative medicine , pathology
The impact of cell factory quality control on material properties is a neglected but critical issue in the fabrication of protein biomaterials, which are unique in merging structure and function. The molecular chaperoning of protein conformational status is revealed here as a potent molecular instructor of the macroscopic properties of self‐assembling, cell‐targeted protein nanoparticles, including biodistribution upon in vivo administration.