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Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery
Author(s) -
Naqvi Syeda M.,
Vedicherla Srujana,
Gansau Jennifer,
McIntyre Tom,
Doherty Michelle,
Buckley Conor T.
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503598
Subject(s) - microcarrier , biomaterial , electrohydrodynamics , materials science , nanotechnology , biomedical engineering , regenerative medicine , tissue engineering , cell , engineering , genetics , physics , quantum mechanics , electric field , biology
Minimally invasive delivery of “living cell factories” consisting of cells and therapeutic agents has gained wide attention for next generation biomaterial device systems for multiple applications including musculoskeletal tissue regeneration, diabetes and cancer. Cellular‐based microcapsules and microcarrier systems offer several attractive features for this particular purpose. One such technology capable of generating these types of systems is electrohydrodynamic (EHD) spraying. Depending on various parameters, including applied voltage, biomaterial properties (viscosity, conductivity) and needle geometry, complex structures and arrangements can be fabricated for therapeutic strategies. The advances in the use of EHD technology are outlined, specifically in the manipulation of bioactive and dynamic material systems to control size, composition and configuration in the development of minimally invasive micro‐scaled biopolymeric systems. The exciting therapeutic applications of this technology, future perspectives and associated challenges are also presented.