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Anticancer Platelet‐Mimicking Nanovehicles
Author(s) -
Hu Quanyin,
Sun Wujin,
Qian Chengen,
Wang Chao,
Bomba Hunter N.,
Gu Zhen
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503323
Subject(s) - drug delivery , in vivo , materials science , tumor cells , nanotechnology , intracellular , cancer research , biochemistry , chemistry , biology , microbiology and biotechnology
A core–shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site‐specific delivery of an extracellularly active drug and an intracellular functional small‐molecular drug, leading to enhanced antitumor efficacy. This PM‐coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.