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Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink
Author(s) -
Colosi Cristina,
Shin Su Ryon,
Manoharan Vijayan,
Massa Solange,
Costantini Marco,
Barbetta Andrea,
Dokmeci Mehmet Remzi,
Dentini Mariella,
Khademhosseini Ali
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503310
Subject(s) - 3d bioprinting , materials science , microfluidics , extrusion , tissue engineering , nanotechnology , viscosity , biomedical engineering , composite material , medicine
A novel bioink and a dispensing technique for 3D tissue‐engineering applications are presented. The technique incorporates a coaxial extrusion needle using a low‐viscosity cell‐laden bioink to produce highly defined 3D biostructures. The extrusion system is then coupled to a microfluidic device to control the bioink arrangement deposition, demonstrating the versatility of the bioprinting technique. This low‐viscosity cell‐responsive bioink promotes cell migration and alignment within each fiber organizing the encapsulated cells.