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A Self‐Assembled Albumin‐Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging
Author(s) -
Chen Qian,
Liu Xiaodong,
Chen Jiawen,
Zeng Jianfeng,
Cheng Zhenping,
Liu Zhuang
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201503194
Subject(s) - nanoprobe , photoacoustic imaging in biomedicine , in vivo , materials science , nanotechnology , computer science , albumin , biomedical engineering , chemistry , optics , biochemistry , medicine , nanoparticle , biology , physics , microbiology and biotechnology
A photoacoustic nanoprobe is self‐assembled from human serum albumin and two types of dye molecules, one is inert to pH and the other is pH sensitive. This probe and the quantitative ratiometric photoacoustic pH imaging method are shown to have high safety, be easy‐to‐operate, and have depth‐independent accuracy for real‐time in vivo pH imaging of entire tumors. These features make them promising for future cancer prognosis and therapeutic planning.