Premium
Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy
Author(s) -
Guo Xing,
Wei Xiao,
Jing Yuting,
Zhou Shaobing
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502865
Subject(s) - nanocarriers , multiple drug resistance , materials science , nanotechnology , micelle , cancer therapy , cancer , drug delivery , drug resistance , medicine , biology , chemistry , aqueous solution , microbiology and biotechnology
A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.