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Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments
Author(s) -
Wang Shue,
Riahi Reza,
Li Na,
Zhang Donna D.,
Wong Pak Kin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502814
Subject(s) - profiling (computer programming) , materials science , gene expression profiling , gene expression , nanotechnology , computational biology , microbiology and biotechnology , gene , biology , biochemistry , computer science , operating system
A gold nanorod‐locked nucleic acid nanobiosensor for dynamic single‐cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single‐cell level.