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Multitheragnostic Multi‐GNRs Crystal‐Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal‐Stem‐Cell Homing, Multimodal Imaging, and Stroke Therapy
Author(s) -
Chen PoJung,
Kang YiDa,
Lin ChenHuan,
Chen SanYuan,
Hsieh ChiaHung,
Chen YouYin,
Chiang ChunWei,
Lee Wei,
Hsu ChungY,
Liao LunDe,
Fan ChihTai,
Li MengLin,
Shyu WoeiCherng
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502784
Subject(s) - materials science , homing (biology) , mesenchymal stem cell , in vivo , nanotechnology , biomedical engineering , microbiology and biotechnology , medicine , biology , ecology
A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi‐gold nanorods crystal‐seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote‐controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long‐term monitoring to achieve therapeutic efficacy.