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Microfluidic Manipulation of Core/Shell Nanoparticles for Oral Delivery of Chemotherapeutics: A New Treatment Approach for Colorectal Cancer
Author(s) -
HasaniSadrabadi Mohammad Mahdi,
Taranejoo Shahrouz,
Dashtimoghadam Erfan,
Bahlakeh Ghasem,
Majedi Fatemeh Sadat,
VanDersarl Jules John,
Janmaleki Mohsen,
Sharifi Fatemeh,
Bertsch Arnaud,
Hourigan Kerry,
Tayebi Lobat,
Renaud Philippe,
Jacob Karl I.
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502697
Subject(s) - nanocarriers , materials science , drug delivery , nanotechnology , microfluidics , drug , nanoparticle , cancer , core (optical fiber) , targeted drug delivery , pharmacology , medicine , composite material
A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug‐delivery system is designed for the oral administration of cancer therapeutics.