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In Situ Formation of Nanofibers from Purpurin18‐Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites
Author(s) -
Zhang Di,
Qi GuoBin,
Zhao YingXi,
Qiao ShengLin,
Yang Chao,
Wang Hao
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502598
Subject(s) - photoacoustic imaging in biomedicine , supramolecular chemistry , conjugate , materials science , nanotechnology , nanofiber , computer science , molecule , chemistry , organic chemistry , mathematical analysis , physics , mathematics , optics
An assembly‐induced retention effect for enhanced tumor photoacoustic (PA) imaging and therapeutics is described. A responsive small‐molecule precursor is prepared that simultaneously self‐assembles into nanofibers in tumor sites that exhibit an assembly‐induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy. This successful proof‐of‐concept study paves the way to develop novel supramolecular biomaterials for cancer diagnostics and therapeutics.