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Hemoglobin‐Based Nanoarchitectonic Assemblies as Oxygen Carriers
Author(s) -
Jia Yi,
Duan Li,
Li Junbai
Publication year - 2016
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502581
Subject(s) - hemoglobin , oxygen , oxygen transport , blood substitute , materials science , nanotechnology , chemistry , biochemistry , organic chemistry
Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen‐transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen‐carrying unit. With advances in nano‐biotechnology, hemoglobin assemblies as artificial oxygen carriers achieve great development. Here, recent progress on hemoglobin‐based oxygen carriers is highlighted in view of two aspects: acellular hemoglobin‐based oxygen carriers and cellular hemoglobin‐based oxygen carriers. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible oxygen carriers.