Premium
Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy
Author(s) -
Song Jibin,
Yang Xiangyu,
Jacobson Orit,
Huang Peng,
Sun Xiaolian,
Lin Lisen,
Yan Xuefeng,
Niu Gang,
Ma Qingjie,
Chen Xiaoyuan
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502486
Subject(s) - photothermal therapy , nanorod , materials science , ethylene glycol , vesicle , peg ratio , nanotechnology , plga , conjugated system , biophysics , nanoparticle , chemical engineering , chemistry , polymer , biochemistry , composite material , biology , membrane , finance , engineering , economics
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic‐co‐glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.