Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy | Zendy

Song Jibin | Zendy; Yang Xiangyu | Zendy; Jacobson Orit | Zendy; Huang Peng | Zendy; Sun Xiaolian | Zendy; Lin Lisen | Zendy; Yan Xuefeng | Zendy; Niu Gang | Zendy; Ma Qingjie | Zendy; Chen Xiaoyuan | Zendy

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Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy

Author(s) -

Song Jibin,

Yang Xiangyu,

Jacobson Orit,

Huang Peng,

Sun Xiaolian,

Lin Lisen,

Yan Xuefeng,

Niu Gang,

Ma Qingjie,

Chen Xiaoyuan

Publication year - 2015

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201502486

Subject(s) - photothermal therapy , nanorod , materials science , ethylene glycol , vesicle , peg ratio , nanotechnology , plga , conjugated system , biophysics , nanoparticle , chemical engineering , chemistry , polymer , biochemistry , composite material , biology , membrane , finance , engineering , economics

A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic‐co‐glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.

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