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Multifunctional Thrombin‐Activatable Polymer Capsules for Specific Targeting to Activated Platelets
Author(s) -
Gunawan Sylvia T.,
Kempe Kristian,
Bonnard Thomas,
Cui Jiwei,
Alt Karen,
Law Lok S.,
Wang Xiaowei,
Westein Erik,
Such Georgina K.,
Peter Karlheinz,
Hagemeyer Christoph E.,
Caruso Frank
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502243
Subject(s) - materials science , thrombin , platelet , serine protease , platelet activation , polymer , protease , biophysics , biochemistry , enzyme , chemistry , immunology , medicine , biology , composite material
Smart poly(2‐oxazoline) (POx)‐based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.