Multifunctional Thrombin‐Activatable Polymer Capsules for Specific Targeting to Activated Platelets | Zendy

Gunawan Sylvia T. | Zendy; Kempe Kristian | Zendy; Bonnard Thomas | Zendy; Cui Jiwei | Zendy; Alt Karen | Zendy; Law Lok S. | Zendy; Wang Xiaowei | Zendy; Westein Erik | Zendy; Such Georgina K. | Zendy; Peter Karlheinz | Zendy; Hagemeyer Christoph E. | Zendy; Caruso Frank | Zendy

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Multifunctional Thrombin‐Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Author(s) -

Gunawan Sylvia T.,

Kempe Kristian,

Bonnard Thomas,

Cui Jiwei,

Alt Karen,

Law Lok S.,

Wang Xiaowei,

Westein Erik,

Such Georgina K.,

Peter Karlheinz,

Hagemeyer Christoph E.,

Caruso Frank

Publication year - 2015

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201502243

Subject(s) - materials science , platelet , polymer , thrombin , platelet activation , nanotechnology , plasminogen activator , combinatorial chemistry , chemistry , biology , immunology , composite material , endocrinology

Smart poly(2‐oxazoline) (POx)‐based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

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