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Nanotheranostics: Congo Red/Rutin‐MNPs with Enhanced Magnetic Resonance Imaging and H 2 O 2 ‐Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice
Author(s) -
Hu Bingbing,
Dai Fengying,
Fan Zhanming,
Ma Guanghui,
Tang Qunwei,
Zhang Xin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502227
Subject(s) - magnetic resonance imaging , rutin , oxidative stress , congo red , materials science , biocompatible material , drug delivery , magnetic nanoparticles , biophysics , nuclear magnetic resonance , nanotechnology , nanoparticle , biomedical engineering , medicine , chemistry , biochemistry , antioxidant , biology , physics , organic chemistry , adsorption , radiology
As nanotheranostics, Congo red/Rutin‐MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H 2 O 2 response, and prevent oxidative stress.