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Engineering Melanin Nanoparticles as an Efficient Drug–Delivery System for Imaging‐Guided Chemotherapy
Author(s) -
Zhang Ruiping,
Fan Quli,
Yang Min,
Cheng Kai,
Lu Xiaomei,
Zhang Lei,
Huang Wei,
Cheng Zhen
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502201
Subject(s) - biocompatibility , materials science , drug delivery , biopolymer , photoacoustic imaging in biomedicine , nanotechnology , drug , melanin , chemotherapy , nanoparticle , biomedical engineering , chemotherapeutic drugs , pharmacology , medicine , chemistry , polymer , biochemistry , physics , optics , metallurgy , composite material
In order to promote imaging‐guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug‐delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging‐guided tumor chemotherapy in living mice.