Premium
Droplet‐Array (DA) Sandwich Chip: A Versatile Platform for High‐Throughput Cell Screening Based on Superhydrophobic–Superhydrophilic Micropatterning
Author(s) -
Popova Anna A.,
Schillo Sebastian M.,
Demir Konstantin,
Ueda Erica,
NesterovMueller A.,
Levkin Pavel A.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502115
Subject(s) - micropatterning , superhydrophilicity , materials science , nanotechnology , throughput , chip , computer science , telecommunications , wetting , composite material , wireless
A droplet‐array (DA) sandwich chip is a miniaturized platform for cell‐based high‐throughput screening. It is based on sandwiching of a glass slide with a preprinted library and a superhydrophobic–superhydrophilic pattern, which consists of thousands of simultaneously formed microdroplets containing cells. The DA sandwich chip allows for one‐step cell seeding, simultaneous initiation of screening, and 1000 times less reagent consumption than a regular 96‐well plate.