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Nanoparticle‐Loaded Protein–Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery
Author(s) -
Lee Jeong Yu,
Carugo Dario,
Crake Calum,
Owen Joshua,
de Saint Victor Marie,
Seth Anjali,
Coussios Constantin,
Stride Eleanor
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502022
Subject(s) - materials science , nanoparticle , polymer , drug delivery , nanotechnology , coating , magnetic nanoparticles , drug , targeted drug delivery , ultrasound , composite material , pharmacology , medicine , physics , acoustics
A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.