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Enzyme‐Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction
Author(s) -
Nguyen Mary M.,
Carlini Andrea S.,
Chien MiaoPing,
Sonnenberg Sonya,
Luo Colin,
Braden Rebecca L.,
Osborn Kent G.,
Li Yiwen,
Gianneschi Nathan C.,
Christman Karen L.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201502003
Subject(s) - myocardial infarction , matrix metalloproteinase , materials science , nanoparticle , enzyme , matrix (chemical analysis) , biomedical engineering , biophysics , nanotechnology , cardiology , medicine , biochemistry , chemistry , composite material , biology
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme‐responsive peptide–polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical‐shaped, discrete materials to network‐like assemblies when acted upon by matrix metalloproteinases (MMP‐2 and MMP‐9), which are up‐regulated in heart tissue post‐myocardial infarction.