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Therapeutic Enzyme‐Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors
Author(s) -
Callmann Cassandra E.,
Barback Christopher V.,
Thompson Matthew P.,
Hall David J.,
Mattrey Robert F.,
Gianneschi Nathan C.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201501803
Subject(s) - in vivo , folate receptor , paclitaxel , drug delivery , nanomedicine , receptor , cancer research , materials science , targeted drug delivery , biophysics , chemistry , cancer , nanotechnology , cancer cell , nanoparticle , biochemistry , medicine , biology , microbiology and biotechnology
An enzyme‐responsive, paclitaxel‐loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof‐of‐concept study demonstrating the utility of enzyme‐responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.