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Rapid 3D Extrusion of Synthetic Tumor Microenvironments
Author(s) -
Grolman Joshua M.,
Zhang Douglas,
Smith Andrew M.,
Moore Jeffrey S.,
Kilian Kristopher A.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201501729
Subject(s) - materials science , extrusion , nanotechnology , biophysics , tumor cells , tumor microenvironment , 3d printing , biomedical engineering , composite material , cancer research , biology , medicine
The spatial positioning of 3D tumor‐mimetic microenvironments , containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.