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Nanocarrier‐Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug‐Delivery Systems
Author(s) -
Tahara Yoshiro,
Mukai Sadaatsu,
Sawada Shinichi,
Sasaki Yoshihiro,
Akiyoshi Kazunari
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201501557
Subject(s) - nanogel , nanocarriers , drug delivery , nanotechnology , materials science , microsphere , computer science , chemical engineering , engineering
A nanocarrier‐integrated bottom‐up method is a promising strategy for advanced drug‐release systems. Self‐assembled nanogels, which are one of the most beneficial nanocarriers for drug‐delivery systems, are tectonically integrated to prepare nanogel‐crosslinked (NanoClik) microspheres. NanoClik microspheres consisting of nanogel‐derived structures (observed by STED microscopy) release “drug‐loaded nanogels” after hydrolysis, resulting in successful sustained drug delivery in vivo.