Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles | Zendy

Chiappini Ciro | Zendy; Campagnolo Paola | Zendy; Almeida Carina S. | Zendy; AbbassiGhadi Nima | Zendy; Chow Lesley W. | Zendy; Hanna George B. | Zendy; Stevens Molly M. | Zendy

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Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles

Author(s) -

Chiappini Ciro,

Campagnolo Paola,

Almeida Carina S.,

AbbassiGhadi Nima,

Chow Lesley W.,

Hanna George B.,

Stevens Molly M.

Publication year - 2015

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201501304

Subject(s) - materials science , cathepsin b , cathepsin , porous silicon , cathepsin d , esophageal cancer , silicon , nanotechnology , cancer , biophysics , enzyme , optoelectronics , biochemistry , biology , medicine

Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide‐based Cathepsin B cleavable sensor over a large array of nanoneedles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.

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