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3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures
Author(s) -
Hong Sungmin,
Sycks Dalton,
Chan Hon Fai,
Lin Shaoting,
Lopez Gabriel P.,
Guilak Farshid,
Leong Kam W.,
Zhao Xuanhe
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201501099
Subject(s) - self healing hydrogels , materials science , sodium alginate , ethylene glycol , biocompatible material , tissue engineering , nanotechnology , 3d bioprinting , composite material , chemical engineering , biomedical engineering , polymer chemistry , sodium , metallurgy , medicine , engineering
A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material.