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Hydrogel Retaining Toxin‐Absorbing Nanosponges for Local Treatment of Methicillin‐Resistant Staphylococcus aureus Infection
Author(s) -
Wang Fei,
Gao Weiwei,
Thamphiwatana Soracha,
Luk Brian T.,
Angsantikul Pavimol,
Zhang Qiangzhe,
Hu CheMing J.,
Fang Ronnie H.,
Copp Jonathan A.,
Pornpattananangkul Dissaya,
Lu Weiyue,
Zhang Liangfang
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201501071
Subject(s) - staphylococcus aureus , methicillin resistant staphylococcus aureus , toxin , microbiology and biotechnology , materials science , self healing hydrogels , bacteria , biology , genetics , polymer chemistry
A hybrid nanomaterial integrating unique toxin‐absorbing nanosponges with hydrogel is developed for local antivirulence therapy against methicillin‐resistant Staphylococcus aureus (MRSA) infection. The hydrogel composition is optimized to retain toxin nanosponges after administration while not compromising toxin transport into the gel for neutralization. Mice treated with the nanosponge–hydrogel hybrid show markedly reduced MRSA skin lesion development.