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Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular Transport
Author(s) -
Kim Minkyu,
Chen Wesley G.,
Kang Jeon Woong,
Glassman Matthew J.,
Ribbeck Katharina,
Olsen Bradley D.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201500752
Subject(s) - nucleoporin , nuclear pore , self healing hydrogels , polymer , materials science , polymer science , nuclear transport , nanotechnology , computer science , nucleus , biology , polymer chemistry , cell nucleus , microbiology and biotechnology , composite material
Nucleoporin‐like polypeptide (NLP) hydrogels are developed by mimicking nucleoporins, proteins that form gel filters regulating transport into the nucleus. Using protein polymers of a minimal consensus repeat, the NLPs selectively enhance transport of cargo–carrier complexes similar to the natural nuclear pore system. The engineered protein gels additionally have tunable mechanical and transport properties and can be biosynthesized at high yield, making them promising materials for advanced separation technologies.